Maternity Secret

Take medicine for pregnant women fear the impact of their fetus. Pregnant women in outpatient common chief complaints of the cold it was unwilling to take medicine because I did not want their own and give birth to deformed children.

If any pharmaceutical or embryonic factor - fetal exposure to the shape or function will result in permanent changes in the original letter teratogenic. The most important thing is the timing of fetal exposure in pregnancy and that a period of time. To this end, the pregnancy is divided into (1) egg from fertilization to implantation; (2) embryonic period of eight weeks from the second and thoughtful; (3) fetal period, from the ninth week of term play.

Seven days after fertilization, fertilized egg does not plant in the endometrium will not be influenced by the medication; fertilized 1-2 weeks, the fertilized egg just plant in the endometrium, the effects of drugs will be a direct result of abortion, if only a small number of cells affected and the compensatory role of the effectiveness of the embryo has happened is likely to continue normal development will not be affected, 3-8 weeks after fertilization, the main organs are the differentiation and development at this stage, the most vulnerable to drugs and the impact of the external environment due to teratogenic . 10 weeks after fertilization, the organ has been divided, because the drug caused by the possibility of teratogenic relatively decreased.

In addition, the drug can pass into the fetal placental barrier in vivo, drugs and their metabolites Get the adequacy of the number of fetuses in order to lead to developmental abnormalities, the mother’s own absorption and metabolism, protein binding and storage, molecular size, price, and the fat-soluble decisions are possible factor. Certain drugs if the latter half of pregnancy has an adverse effect is indeed taking. For example, tetracycline may lead to deciduous teeth have yellow or brown coloring.

Food and Drug Administration’s drug classification

Occurred in the 1960s thalidomide incident, resulting in a seal-shaped teratism abuse. Therefore, in the United States take the lead in the 1980s, in the territory of the United States pharmaceuticals, pregnant women must provide information on drug safety information. The United States Food and Drug Administration FDA to drugs and drugs on the fetus may be the adverse effects set up five categories (divided into 5 ABCDE). These categories are intended for the use of these drugs during pregnancy on the mother and fetus may be the benefits and risks to provide guidance.

1. Risk-free
2. No risk to human evidence
3. Risk can not be ruled out
4. Has the risk
5. Prohibition of the Use in pregnant women

Therefore, pregnant women must consult a physician to comply with medication orders, and the doctors out of medicine by the majority of all A, B-class, only the clinical benefits for the mother, will open C-class drug. However, no C-level cases resulted in fetal malformations.

Situation for specific drugs

The first three months of pregnancy, the fetus are most likely to be affected, a small number of drugs in the last three months or before birth, this will result in maternal or neonatal risk. In fact needs to be because the fetus in pregnant women and are very difficult to do tests, which will cause a great deal of controversy, it was classified as A-class drugs rarely, B-class times, and the C-class the largest number of drugs.

The choice of drugs in pregnancy

To give necessary care to pregnant women drugs rational drug use in order to guarantee the safety of pregnant women and fetuses. Pregnancy-induced hypertension (pregnancyinducedhypertension) deal with the principles: as a result of antihypertensive drugs in general will reduce the uterus - placenta blood flow. Pregnancy is more applicable for antihypertensive drugs mcthyldopa, labctalol, hydralazine, prazosin, a role mainly in the central nervous system, while minimizing the impact of peripheral circulatory system.

Have hyperthyroidism in pregnancy, light condition, and generally do not need drug treatment; remain in serious condition given anti-thyroid drug treatment. Because of such drugs through the placenta, should pay attention to dose, otherwise it will create fetal thyroid have hypothyroidism and goiter. Should pay attention to the radioisotope iodine treatment of a pregnant disabled.

Gestational diabetes, insulin is the safest drug to lower blood sugar. Pregnant women, acceptance of anti-infective therapy are also many opportunities. Cephalosporins for blood - placental barrier penetration is not high, low toxicity of these drugs may be safe for pregnant women.

The use of steroids: Animal experiments showed that steroid treatment given to the fetus can increase blood steroid values, and the promotion of pulmonary surfactant of sophisticated, applied to pregnant 24-34 weeks pregnant women may be premature to reduce the occurrence of neonatal RDS, intraventricular hemorrhage, reduce mortality. Intramuscular injection of 12mg of treatment, including betamethasone, separated from the first 24 hours after injection, a total of 2, or 8mg every 12 hours by intramuscular injection of dexamethasone were injected 4.

Clinical obstetrics and drugs given to pregnant women physicians will take into account the fetus may be induced endometrial exposure to the risk of teratogenic drugs, on the other hand should not be misleading or excessive emphasis on the teratogenicity of drugs, causing great anxiety in pregnant women resulting from unnecessary abortion or to pregnant women will need to stop treatment. Pregnant women are often necessary to use a particular drug treatment situation. However, apart from a small number of drugs, the majority of obstetric doctors to prescribe the drug are quite safe, In addition, because theoretically the risk of drug treatment for pregnant women without the disease itself, this may not have pregnant women and fetuses, causing more dangerous.